Filmmaker Judd Apatow has intentionally gained about 15 pounds over four years while taking the maximum dose of Ozempic, his wife Leslie Mann revealed on the August 27 episode of Jimmy Kimmel Live!.
Speaking to guest host Jelly Roll, Mann explained that her husband of nearly 30 years deliberately overrides the appetite-suppressing effects of the popular weight loss medication.
Jelly Roll, who has previously discussed his own experience with weight loss drugs, quipped that the 58-year-old director was overeating Ozempic.
Mann, who shares daughters Maude Apatow, 28, and Iris Apatow, 23, with the 40-Year-Old Virgin director, said Apatow takes pride in defying the drug. "He's very proud of the fact that the pharmaceutical companies don't have control over him," she said. "It's so weird."
Apatow previously outlined his battle against the medication during a 2024 stand-up routine at the Comedy Cellar, captured in a Facebook clip. "It makes you nauseous so you don't wanna eat. But I take it as a challenge to eat through the nausea," Apatow told the crowd, joking he would "f--king prove this medicine doesn't work."
The Knocked Up director revealed he spent $40,000 on the ongoing test. "Sometimes I'll eat ice cream and shoot myself with Ozempic at the same time to see who wins. Just to see who wins the battle," Apatow said, noting it had been a draw so far.
Speaking to Vulture in 2024, Apatow explained his motivation. "My goal wasn't to lose weight; my goal was to outrun Ozempic and prove that you can gain weight on this thing," he said. "I was almost offended at the idea that a drug could make me lose weight. Like, 'F--k you, I'm going to gain weight. Who do you think you are? You think you're stronger than this? My low self-esteem, which is sedated by food, cannot be stopped by your silly injection.'"
Apatow admitted he did not realize he was being prescribed Ozempic when a nutritionist first gave him the shots, leaving Mann shocked. Mann told him: "You never asked what was in a shot. You literally inject yourself with a mystery juice." Apatow conceded he is still taking the drug, saying: "It doesn't work at all. Look at me; I look terrible. I want to look like Sharon Osbourne. I am not making this work."
Celebrity Weight Loss Drug Successes
Actress Chrissy Metz gave GLP-1 medications a shot through telehealth company Ro after years of feeling very skeptical of starting a GLP-1. The This Is Us star, currently performing eight Broadway shows a week in & Juliet, told E! News in an exclusive August 2026 interview that after a friend conducted very thorough research, she found the medication quieted food noise, reduced inflammation, improved her blood work, and gave her an overall feeling of space and creativity without doing it purely for vanity's sake.
Media personality Trisha Paytas turned to Zepbound after gaining 80 pounds across back-to-back pregnancies with Malibu Barbie, Elvis, and Aquaman. Paytas told People in June 2026 that after years of starving herself, killing herself in the gym, and trying all the fad diets, she lost 26 pounds in six weeks and is now contemplating a 2027 marathon after living 38 years obsessing about food.
Tennis star Serena Williams partnered with Ro after struggling to lose weight following the 2017 birth of her daughter Alexis. Williams detailed on Today in 2025 that despite running, walking for hours, and playing professional sports, GLP-1 medication helped her drop 31 pounds while rejecting claims that the treatment is a shortcut.
Oprah Winfrey revealed in December 2023 that she was taking a weight loss medication, noting on a January 2025 episode of The Oprah Podcast that she felt like an anomaly for admitting it. Winfrey explained that taking a GLP-1 made her realize thin people did not simply possess more willpower, but were naturally not thinking about food constantly.
Singer Meghan Trainor and actor husband Daryl Sabara began taking low doses of Mounjaro alongside exercise and balanced meals following the 2021 birth of their son Riley and completing the 75 Hard challenge. Trainor explained on their Workin' On It podcast in April 2025 that the couple embarked on the journey together after hearing positive reports from friends and doctors.
Queer Eye star Jonathan Van Ness shared in an October 2025 TikTok video that they began taking a GLP-1 following a 2023 medical issue and colonoscopy, resulting in a 70-pound weight loss alongside Solidcore Pilates while emphasizing body neutrality. Comedian Rosie O'Donnell has used Mounjaro since late 2022, showcasing her weight loss on Instagram in May 2025 with hashtags including #mounjaro, #weightloss, and #bodydismorphia.
Jon & Kate Plus 8 alum Jon Gosselin told Page Six in April 2024 that he lost 32 pounds in two months using semaglutide, expressing regret for not starting 10 years earlier. Real Housewives of Dubai star Caroline Stanbury shared on her Uncut & Uncensored podcast in May 2024 that she used Ozempic after a midlife crisis at 45, calling it one of the best tools available.
Real Housewives of New Jersey star Jennifer Aydin declared on Watch What Happens Live in July 2024 that she uses Mounjaro rather than Ozempic, saying she loves her weight and high energy level. Beverly Hills, 90210 star Tori Spelling revealed on her misSPELLING podcast in April 2024 that while Ozempic failed following the 2017 birth of her son Beau, switching to Mounjaro successfully helped her lose weight.
Adverse Effects and Failed Attempts
Model Lottie Moss, sister of Kate Moss, called taking Ozempic the worst decision I ever made on her Dream On podcast in September 2024. After taking a dosage intended for individuals weighing 220 pounds or more, Moss suffered severe dehydration and a seizure that led to emergency room treatment.
Trainwreck star Amy Schumer called out celebrities for hiding their GLP-1 use on Watch What Happens Live in June 2023, while revealing she stopped taking Ozempic in 2022 because severe nausea left her too sick to play with her son Gene. Schumer noted that when she previously had liposuction, she was open about it.
Model Brooks Nader told Us Weekly in December 2024 that she stopped taking Ozempic after joining Dancing With the Stars due to nausea and a loss of workout motivation. Bonnie Chapman, daughter of Dog the Bounty Hunter, lost 58 pounds in 10 months using Tirzepatide and diet changes after quitting Ozempic, telling E! News in November 2024 that Ozempic made her constantly nauseous.
Real Housewives of Atlanta alum Kandi Burruss shared in June 2024 that Ozempic failed to curb her appetite, leaving her eating appetizers, meals, and desserts while feeling depressed that it did not work for her. Former Girls Next Door star Kendra Wilkinson discarded her first GLP-1 injection in April 2025, but resumed her journey in March 2026 with a focus on overall energy and transparent support.
Actor Tracy Morgan credited Ozempic with suppressing his appetite on Today in August 2023, before joking on The Tonight Show in March 2024 that he out-ate Ozempic to gain 40 pounds, later clarifying to E! News that the comment was a joke. Reality star Whitney Leavitt disclosed on YouTube in January 2023 that she used semaglutide injections to lose weight before appearing on Secret Lives of Mormon Wives and Dancing With the Stars.
Celebrity Debate and Alternative Views
Comedian Nikki Glaser defended Ozempic on The Tonight Show in March 2025, asserting that shame surrounding the drug comes from thin people wanting others to remain overweight. Sharon Osbourne told E! News in September 2023 that she lost 42 pounds on Ozempic, calling weight loss aids perfectly fine, while her daughter Kelly Osbourne praised the medication in January 2024 as an alternative to working out.
Little Mix alum Jade Thirlwall told The Guardian in August 2025 that she faces a daily battle not to take Ozempic, avoiding it due to her personal history with eating disorders. Singer Lizzo shared on the Just Trish podcast in June 2025 that she discontinued weight loss injectables early in her journey, favoring mindset and self-discipline over medication.
Real Housewives of New York City star Jessel Taank shut down Ozempic rumors in October 2024, telling Us Weekly she hates the drug and would never use needles. The Hills star Heidi Montag told Page Six in December 2023 that she shed 22 pounds without Ozempic, opting for sustainable hard work over shortcuts.
Actress Kate Winslet told The New York Times Magazine in March 2024 that she was unfamiliar with Ozempic, calling injectables terrible after learning how they function. Brooke Burke noted to Fox News Digital that Ozempic carries both benefits and dangers, while Raven-Symone told E! News that medications should be reserved for those with medical need rather than glamazon purposes. Pioneer Woman host Ree Drummond stated on her blog in March 2024 that her 50-pound weight loss in 2022 did not involve Ozempic, while expressing complete support for those who choose it.
